Brain region specific molecular activity changes in the mouse brain induced by reversal learning

Focused ultrasound modulates region-specific brain activity

We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the animal's somatomotor and visual areas, as guided by anatomical and functional information from magn...

Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain

RATIONALE Chorioamnionitis has been associated with increased risk for fetal brain damage. Although, it is now accepted that synaptic dysfunction might be responsible for functional deficits, synaptic densities/numbers after a fetal inflammatory challenge have not been studied in different regions yet. Therefore, we tested in this study the hypothesis that LPS-induced chorioamnionitis caused pr...

Brain-site-specific proteome changes induced by neuronal P60TRP expression.

p60 transcription regulator protein (p60TRP) facilitates the processing of the amyloid precursor protein towards the non-amyloidogenic pathway by inhibiting the β-secretase action. This protein was initially identified to be downregulated in the temporal lobe of brains from Alzheimer's disease patients. p60TRP is one of the G-protein-coupled receptor (GPCR)-associated proteins which directly in...

Brain Functional Connectivity Changes During Learning of Time Discrimination

The human brain is a complex system consist of connected nerve cells that adapts with and learn from the environment by changing its regional activities. Synchrony between these regional activities called functional network changes during the life, and with learning of new skills. Time perception and interval discrimination are among the most necessary skills for the human being to perceive mot...

Differential Brain Activity During Emotional vs . Non - emotional Reversal Learning